反应机理

反应实例

【Tet. Lett., 1998, 39, 4095】

Amino acid (7). To 1 (0.5 mmol) in 20 mL MeCN were added finely powdered K2CO3 (3 mmol), TBAHS (0.1 mmol), and α,α-dibromo-o-xylene 5 (0.5 mmol). The mixture was heated at 70–80℃，until 5 was consumed (TLC). Filtration, washing of the solid with MeCN, filtrate evaporation and chromatography afforded isocyanoester 6 (93%). To the latter (0.16 mmol) in 5 mL abs EtOH at r.t. wasadded a few drops of conc HCl and after a few hours stirring the solution was evaporated. The resultingHCl salt in H2O was washed with ether and NH4OH was added to the aq layer to pH 9–10. Extractionwith EA and workup gave 7 (90%).

【J. Org. Chem., 2000, 65, 1359】

相关文献

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编译自：Organic Syntheses Based On Name Reactions, 3RdEd, A. Hassner, Page 269-270.