在碱和双氧水存在下，将2’-羟基查尔酮（2’-hydroxychalcones）转化为 2-芳基-3-羟基-4H-1苯并呋喃-4-酮（黄酮醇 ，flavonols）。

反应机理

副反应

反应实例

参考文献

1. Algar, J.; Flynn, J. P. Proc. Roy. Irish. Acad. 1934, 42B, 1.

2. Oyamada, T. J. Chem. Soc. Japan 1934, 55, 1256.

3. Oyamada, T. Bull. Chem. Soc. Jpn. 1935, 10, 182.

4. Wheeler, T.S. Rec. of Chem. Prog. 1957, 18, 133. (Review)

5. Smith, M. A.; Neumann, R. M.; Webb, R. A. J. Heterocycl. Chem. 1968, 5, 425.

6. Rao, A. V. S.; Rao, N. V. S. Current Science 1974, 43, 477.

7. Cullen, W. P.; Donnelly, D. M. X.; Keenan, A. K.; Kennan, P. J.; Ramdas, K. J. Chem.

Soc., Perkin Trans. 1 1975, 1671.

8. Wagner, H.; Farkas, L. In The Flavonoids; Harborne, J. B.; Mabry, T. J.; Mabry H.,

Eds.; Academic Press: New York, 1975; p 127. (Review).

9. Wollenweber, E. In The Flavonoids: Advances in Research; Harborne, J. B.; Mabry,

T. J., Eds; Chapman and Hall: New York, 1982; p 189. (Review).

10. Jain, A. C.; Gupta, S. M.; Sharma, A. Bull. Chem. Soc. Jpn. 1983, 56, 1267.

11. Prasad, K. J. Rajendra; Iyer, C. S. Rukmani; Iyer, P. R. Indian J. Chem., Sect. B 1983, 22B, 693.

12. Wollenweber, E. In The Flavonoids: Advances in Research since 1986; Harborne, J.

B., Ed.; Chapman and Hall: New York, 1994, p 259. (Review).

13. Bennett, M.; Burke, A. J.; O'Sullivan, W. I. Tetrahedron 1996, 52, 7163.

14. Sobottka, A. M.; Werner, W.; Blaschke, G.; Kiefer, W.; Nowe, U.; Dannhardt, G.;

Schapoval, E. E. S.; Schenkel, E. P.; Scriba, G. K. E. Arch. Pharm. 2000, 333, 205.

15. Bohm, B. A.; Stuessy, T. F. Flavonoids of the Sunflower Family (Asteraceae);

Springer-Verlag: New York, 2001. (Review).

编译自：Name Reactions （A Collection of Detailed Reaction Mechanisms）, Jie Jack Li, Algar-Flynn-Oyamada Reaction，page 5-7.