芳香族直接氟化法一般采用F2-N2体系，对反应容器及反应条件控制的要求较高，而且用该方法时易产生芳环上二取代或多取代副产物，如要得到一取代为主产物，一般要在芳环上有一个强拉电子的定位基团（硝基、羰基等）例如：
近年来，随着氟化学研究的发展，出现了一些温和的氟代试剂（F-TEDA-BF3 SelectfluorTM等），使得芳环上直接氟代制备芳香单氟代物更简单易行，如：
实例：
Procedure：A solution of the pyrrole compound 1 (0.33 g,2.00 mmol, 1.0 equiv) and Selectfluor™ (0.71 g, 2.00 mmol, 1.0 equiv) in MeCN (20 mL) was refluxed in a MLSSTART 1500 microwave synthesizer at 70 to 72 °C for 5 min. The reaction was quenched by addition of 50 mL H2O to the cooled solution followed by the addition of 50 mL CHCl3. The layers were separated and the aqueous phase was extracted with CHCl3 (3 x50 mL). The combined organic phases were dried with MgSO4 and the solvent was removed under reduced pressure, followed by flash column chromatography PE/TBME (15:1) to afforded 2 (0.15 g, 40%) as light yellow oil.
芳环碳氢键氟化方法汇总
除了上述方法外，本文我们整理了部分芳环的其他直接氟化方法，分享给大家，如果有没有涉及到的实用方法，小伙伴们也可以推荐给我们。
来源：览博网
